At the same time, the occurrence of Debye or Charge screening when exposed in high salt concentration suchlike as physiological fluids restrict in ground of clinical applications as assay requirements that includes expansive sample pre-treatment process steps, this technology suffer from noise signals which restrict their detection limit. Field-Effect Transistors (FET) based biosensors provide easy signal read-out capabilities, lower detection limit, and higher sensitivity. The major drawback of these types of sensors it lacks because of its material degradation of the gate insulators and longer-term drift performance which possess instability in solution. ISFET’s based sensor has been processed for the very same as they deliver faster response, higher sensitivity, higher resolution, and label-free detection. Among various types of biological sensors, the semiconductor biosensors gathered attraction due to their superior advantage in the process of integration, multifunction, and miniaturization.

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